Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium
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چکیده
منابع مشابه
Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes.
Eya1 encodes a transcriptional co-activator and is expressed in cranial sensory placodes. It interacts with and functions upstream of the homeobox gene Six1 during otic placodal development. Here, we have examined their role in cranial sensory neurogenesis. Our data show that the initial cell fate determination for the vestibuloacoustic neurons and their delamination appeared to be unaffected i...
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The murine Six gene family, homologous to Drosophila sine oculis (so) which encodes a homeodomain transcription factor, is composed of six members (Six1-6). Among the six members, only the Six2 gene has been previously shown to be expressed early in kidney development, but its function is unknown. We have recently found that the Six1 gene is also expressed in the kidney. In the developing kidne...
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The mammalian inner ear detects sound with the organ of Corti, an intricately patterned region of the cochlea in which one row of inner hair cells and three rows of outer hair cells are surrounded by specialized supporting cells. The organ of Corti derives from a prosensory domain that runs the length of the cochlear duct and is bounded by two nonsensory domains, Kölliker's organ on the neural ...
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The mammalian auditory sensory epithelium, the organ of Corti, comprises the hair cells and supporting cells that are pivotal for hearing function. The origin and development of their precursors are poorly understood. Here we show that loss-of-function mutations in mouse fibroblast growth factor receptor 1 (Fgfr1) cause a dose-dependent disruption of the organ of Corti. Full inactivation of Fgf...
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The infrequency of mitotic figures led to dispute amongst early workers as to the occurrence of cell division in adult mammalian airway epithelium [30, 63, 83, 227]. It was not until 1951 that quantitative work in the respiratory tract began to concentrate on the distal (i.e. respiratory) portion of the lung (reviewed by BERTALANFFY (20, 21], KAUFFMAN [132], and MASSE et al. [159]). Studies of ...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2017
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1006967